I have familiarized myself with them.
But eventually, though we may chase these hidden particles and "strings," and immerse ourselves in theory-play, we're going to hit a wall. Or perhaps more accurately, a door. A door which leads into practicality of the deeper and stranger elements of the theories of quantum physics and other unknown elements of reality.
Your scientists have scratched the surface of this yet have refrained at large from pursuing this rabbit hole. But they'll run out of room the farther they go.
The nature of the universe is still unknown to us. I would say, completely. Our scientific understanding is, mmm, negligible, you might say, compared with the total sum of the universe's workings. One of these elements, you see, is the many-worlds interpretation of quantum mechanics, which is correct. Not only that, but it is accessible.
Your scientists might discover this but will not be the ones to bring it to light, however. This is where everything comes full-circle.